Effect of micro-cracks on the angiogenesis and osteophyte development during degenerative joint disease

  • Ewa Irena Bednarczyk Warsaw University of Technology, Department of Construction Engineering and Biomedical Engineering
  • Tomasz Lekszycki
  • Wojciech Glinkowski

Abstract

Osteoarthritis is one of the most common types of arthritis, characterized by the development of osteophytes. The main cause of joint degeneration is mechanical loading, but there are also several other factors which influence the growth of osteophytes. In order to formulate a mathematical model of bone spurs’ development we have selected the most important factors, such as angiogenesis, micro-damage of the tissue structure and cell signalling. The proposed system of integro-differential equations describes the degenerative changes in the joint. Numerical calculations were implemented into the COMSOL Multiphysics software and the results thus obtained reflect relations between certain parameters and variables. The results correspond to medical observations.

Keywords

Osteoarthritis; Angiogenesis; Mathematical modelling; Mechanical loading; Micro-damage; Osteophytes,
Published
Mar 25, 2018
How to Cite
BEDNARCZYK, Ewa Irena; LEKSZYCKI, Tomasz; GLINKOWSKI, Wojciech. Effect of micro-cracks on the angiogenesis and osteophyte development during degenerative joint disease. Computer Assisted Methods in Engineering and Science, [S.l.], v. 24, n. 3, p. 149–156, mar. 2018. ISSN 2299-3649. Available at: <http://cames.ippt.gov.pl/index.php/cames/article/view/191>. Date accessed: 26 apr. 2018.
Section
Articles